Preliminary evidence for an association between a dopamine D3 receptor gene variant and obsessive‐compulsive personality disorder in patients with major depression
Identifieur interne : 002309 ( Main/Exploration ); précédent : 002308; suivant : 002310Preliminary evidence for an association between a dopamine D3 receptor gene variant and obsessive‐compulsive personality disorder in patients with major depression
Auteurs : Katrina J. Light [Nouvelle-Zélande] ; Peter R. Joyce [Nouvelle-Zélande] ; Suzanne E. Luty [Nouvelle-Zélande] ; Roger T. Mulder [Nouvelle-Zélande] ; Christropher M. A. Frampton [Nouvelle-Zélande] ; Laura R. M. Joyce [Nouvelle-Zélande] ; Allison L. Miller [Nouvelle-Zélande] ; Martin A. Kennedy [Nouvelle-Zélande]Source :
- American Journal of Medical Genetics Part B: Neuropsychiatric Genetics [ 1552-4841 ] ; 2006-06-05.
English descriptors
- Teeft :
- Allele, Allele frequencies, Andrea bartram, Anxiety disorder diagnoses, Blood sample, Character inventory, Christchurch, Christchurch school, Clinical interview, Clinical psychologist, Clinical sample, Compulsive personality disorder, Conditional independence, Consistent association, Consistent trend, Depressed individuals, Depressed patients, Disorder, Dopamine, Dopamine receptors, Dopamine release, Drd3, Drd3 agonists, Drd3 genotype, Drd3 polymorphism, Drd3 polymorphisms, Epidemiological survey, Exact test, Family study, Gender, Genet part, Genotype, Independent samples, Knockout mice, Locomotor activity, Locomotor inhibition, Major depression, Male gender, Medicine health sciences, Motor control, Neural transm, Neuropsychiatric interview, Obsessivecompulsive disorder, Ocpd, Ocpd diagnosis, Ocpd symptoms, Original sample, Original study, Overall association, Panic disorder, Personality disorder, Personality disorders, Personality trait, Personality traits, Polymorphism, Potential predictors, Predictor, Preliminary evidence, Psychiatric disorders, Psychological medicine, Receptor, Receptor gene variant, Recurrent depression, Replication, Replication sample, Replication samples, Risk factor, Second replication sample, Temperament traits.
Abstract
We have previously reported that the Ser9Gly dopamine D3 receptor (DRD3) polymorphism was associated with increased rates of obsessive‐compulsive personality disorder (OCPD) symptomology. We tested the replicability of this association within a further two independent groups of individuals with a history of depression, from a clinical sample (n = 149) and a family study (n = 213). The data from the replication samples and the original sample, within which the association was found, were compiled within a meta‐analysis. Although the independent samples did not replicate the original finding, the meta‐analysis elucidated significant evidence supporting the association. An individual with Gly/Gly genotype is 2.4 (P = 0.017) times more likely to be diagnosed with OCPD. Male gender was also found to be a significant predictor of OCPD diagnosis (OR = 2.82, P = 0.001). An exploration of an association of DRD3 with Axis I anxiety disorder diagnoses and Temperament and Character Inventory (TCI) traits, in particular persistence, revealed no support for an association. We conclude that DRD3 may contribute to the development of OCPD. © 2006 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/ajmg.b.30308
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001154
- to stream Istex, to step Curation: 001101
- to stream Istex, to step Checkpoint: 000F06
- to stream Main, to step Merge: 002314
- to stream Main, to step Curation: 002309
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Preliminary evidence for an association between a dopamine D3 receptor gene variant and obsessive‐compulsive personality disorder in patients with major depression</title><author><name sortKey="Light, Katrina J" sort="Light, Katrina J" uniqKey="Light K" first="Katrina J." last="Light">Katrina J. Light</name></author><author><name sortKey="Joyce, Peter R" sort="Joyce, Peter R" uniqKey="Joyce P" first="Peter R." last="Joyce">Peter R. Joyce</name></author><author><name sortKey="Luty, Suzanne E" sort="Luty, Suzanne E" uniqKey="Luty S" first="Suzanne E." last="Luty">Suzanne E. Luty</name></author><author><name sortKey="Mulder, Roger T" sort="Mulder, Roger T" uniqKey="Mulder R" first="Roger T." last="Mulder">Roger T. Mulder</name></author><author><name sortKey="Frampton, Christropher M A" sort="Frampton, Christropher M A" uniqKey="Frampton C" first="Christropher M. A." last="Frampton">Christropher M. A. Frampton</name></author><author><name sortKey="Joyce, Laura R M" sort="Joyce, Laura R M" uniqKey="Joyce L" first="Laura R. M." last="Joyce">Laura R. M. Joyce</name></author><author><name sortKey="Miller, Allison L" sort="Miller, Allison L" uniqKey="Miller A" first="Allison L." last="Miller">Allison L. Miller</name></author><author><name sortKey="Kennedy, Martin A" sort="Kennedy, Martin A" uniqKey="Kennedy M" first="Martin A." last="Kennedy">Martin A. Kennedy</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:A4F78EDBF3F904AB205F89D64F4B27BA47774FE7</idno><date when="2006" year="2006">2006</date><idno type="doi">10.1002/ajmg.b.30308</idno><idno type="url">https://api.istex.fr/ark:/67375/WNG-L96SPX26-3/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">001154</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001154</idno><idno type="wicri:Area/Istex/Curation">001101</idno><idno type="wicri:Area/Istex/Checkpoint">000F06</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000F06</idno><idno type="wicri:doubleKey">1552-4841:2006:Light K:preliminary:evidence:for</idno><idno type="wicri:Area/Main/Merge">002314</idno><idno type="wicri:Area/Main/Curation">002309</idno><idno type="wicri:Area/Main/Exploration">002309</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Preliminary evidence for an association between a dopamine D3 receptor gene variant and obsessive‐compulsive personality disorder in patients with major depression</title><author><name sortKey="Light, Katrina J" sort="Light, Katrina J" uniqKey="Light K" first="Katrina J." last="Light">Katrina J. Light</name><affiliation wicri:level="1"><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>Department of Psychological Medicine, Christchurch School of Medicine & Health Sciences, Christchurch</wicri:regionArea><wicri:noRegion>Christchurch</wicri:noRegion></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Nouvelle-Zélande</country></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>Correspondence address: Department of Psychological Medicine, Christchurch School of Medicine & Health Sciences, PO Box 4345, Christchurch</wicri:regionArea><wicri:noRegion>Christchurch</wicri:noRegion></affiliation></author><author><name sortKey="Joyce, Peter R" sort="Joyce, Peter R" uniqKey="Joyce P" first="Peter R." last="Joyce">Peter R. Joyce</name><affiliation wicri:level="1"><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>Department of Psychological Medicine, Christchurch School of Medicine & Health Sciences, Christchurch</wicri:regionArea><wicri:noRegion>Christchurch</wicri:noRegion></affiliation></author><author><name sortKey="Luty, Suzanne E" sort="Luty, Suzanne E" uniqKey="Luty S" first="Suzanne E." last="Luty">Suzanne E. Luty</name><affiliation wicri:level="1"><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>Department of Psychological Medicine, Christchurch School of Medicine & Health Sciences, Christchurch</wicri:regionArea><wicri:noRegion>Christchurch</wicri:noRegion></affiliation></author><author><name sortKey="Mulder, Roger T" sort="Mulder, Roger T" uniqKey="Mulder R" first="Roger T." last="Mulder">Roger T. Mulder</name><affiliation wicri:level="1"><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>Department of Psychological Medicine, Christchurch School of Medicine & Health Sciences, Christchurch</wicri:regionArea><wicri:noRegion>Christchurch</wicri:noRegion></affiliation></author><author><name sortKey="Frampton, Christropher M A" sort="Frampton, Christropher M A" uniqKey="Frampton C" first="Christropher M. A." last="Frampton">Christropher M. A. Frampton</name><affiliation wicri:level="1"><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>Department of Psychological Medicine, Christchurch School of Medicine & Health Sciences, Christchurch</wicri:regionArea><wicri:noRegion>Christchurch</wicri:noRegion></affiliation></author><author><name sortKey="Joyce, Laura R M" sort="Joyce, Laura R M" uniqKey="Joyce L" first="Laura R. M." last="Joyce">Laura R. M. Joyce</name><affiliation wicri:level="1"><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>Department of Psychological Medicine, Christchurch School of Medicine & Health Sciences, Christchurch</wicri:regionArea><wicri:noRegion>Christchurch</wicri:noRegion></affiliation></author><author><name sortKey="Miller, Allison L" sort="Miller, Allison L" uniqKey="Miller A" first="Allison L." last="Miller">Allison L. Miller</name><affiliation wicri:level="1"><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>Department of Pathology, Christchurch School of Medicine & Health Sciences, Christchurch</wicri:regionArea><wicri:noRegion>Christchurch</wicri:noRegion></affiliation></author><author><name sortKey="Kennedy, Martin A" sort="Kennedy, Martin A" uniqKey="Kennedy M" first="Martin A." last="Kennedy">Martin A. Kennedy</name><affiliation wicri:level="1"><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>Department of Pathology, Christchurch School of Medicine & Health Sciences, Christchurch</wicri:regionArea><wicri:noRegion>Christchurch</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">American Journal of Medical Genetics Part B: Neuropsychiatric Genetics</title><title level="j" type="alt">AMERICAN JOURNAL OF MEDICAL GENETICS PART B: NEUROPSYCHIATRIC GENETICS</title><idno type="ISSN">1552-4841</idno><idno type="eISSN">1552-485X</idno><imprint><biblScope unit="vol">141B</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="409">409</biblScope><biblScope unit="page" to="413">413</biblScope><biblScope unit="page-count">5</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2006-06-05">2006-06-05</date></imprint><idno type="ISSN">1552-4841</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1552-4841</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Allele</term><term>Allele frequencies</term><term>Andrea bartram</term><term>Anxiety disorder diagnoses</term><term>Blood sample</term><term>Character inventory</term><term>Christchurch</term><term>Christchurch school</term><term>Clinical interview</term><term>Clinical psychologist</term><term>Clinical sample</term><term>Compulsive personality disorder</term><term>Conditional independence</term><term>Consistent association</term><term>Consistent trend</term><term>Depressed individuals</term><term>Depressed patients</term><term>Disorder</term><term>Dopamine</term><term>Dopamine receptors</term><term>Dopamine release</term><term>Drd3</term><term>Drd3 agonists</term><term>Drd3 genotype</term><term>Drd3 polymorphism</term><term>Drd3 polymorphisms</term><term>Epidemiological survey</term><term>Exact test</term><term>Family study</term><term>Gender</term><term>Genet part</term><term>Genotype</term><term>Independent samples</term><term>Knockout mice</term><term>Locomotor activity</term><term>Locomotor inhibition</term><term>Major depression</term><term>Male gender</term><term>Medicine health sciences</term><term>Motor control</term><term>Neural transm</term><term>Neuropsychiatric interview</term><term>Obsessivecompulsive disorder</term><term>Ocpd</term><term>Ocpd diagnosis</term><term>Ocpd symptoms</term><term>Original sample</term><term>Original study</term><term>Overall association</term><term>Panic disorder</term><term>Personality disorder</term><term>Personality disorders</term><term>Personality trait</term><term>Personality traits</term><term>Polymorphism</term><term>Potential predictors</term><term>Predictor</term><term>Preliminary evidence</term><term>Psychiatric disorders</term><term>Psychological medicine</term><term>Receptor</term><term>Receptor gene variant</term><term>Recurrent depression</term><term>Replication</term><term>Replication sample</term><term>Replication samples</term><term>Risk factor</term><term>Second replication sample</term><term>Temperament traits</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We have previously reported that the Ser9Gly dopamine D3 receptor (DRD3) polymorphism was associated with increased rates of obsessive‐compulsive personality disorder (OCPD) symptomology. We tested the replicability of this association within a further two independent groups of individuals with a history of depression, from a clinical sample (n = 149) and a family study (n = 213). The data from the replication samples and the original sample, within which the association was found, were compiled within a meta‐analysis. Although the independent samples did not replicate the original finding, the meta‐analysis elucidated significant evidence supporting the association. An individual with Gly/Gly genotype is 2.4 (P = 0.017) times more likely to be diagnosed with OCPD. Male gender was also found to be a significant predictor of OCPD diagnosis (OR = 2.82, P = 0.001). An exploration of an association of DRD3 with Axis I anxiety disorder diagnoses and Temperament and Character Inventory (TCI) traits, in particular persistence, revealed no support for an association. We conclude that DRD3 may contribute to the development of OCPD. © 2006 Wiley‐Liss, Inc.</div></front></TEI><affiliations><list><country><li>Nouvelle-Zélande</li></country></list><tree><country name="Nouvelle-Zélande"><noRegion><name sortKey="Light, Katrina J" sort="Light, Katrina J" uniqKey="Light K" first="Katrina J." last="Light">Katrina J. Light</name></noRegion><name sortKey="Frampton, Christropher M A" sort="Frampton, Christropher M A" uniqKey="Frampton C" first="Christropher M. A." last="Frampton">Christropher M. A. Frampton</name><name sortKey="Joyce, Laura R M" sort="Joyce, Laura R M" uniqKey="Joyce L" first="Laura R. M." last="Joyce">Laura R. M. Joyce</name><name sortKey="Joyce, Peter R" sort="Joyce, Peter R" uniqKey="Joyce P" first="Peter R." last="Joyce">Peter R. Joyce</name><name sortKey="Kennedy, Martin A" sort="Kennedy, Martin A" uniqKey="Kennedy M" first="Martin A." last="Kennedy">Martin A. Kennedy</name><name sortKey="Light, Katrina J" sort="Light, Katrina J" uniqKey="Light K" first="Katrina J." last="Light">Katrina J. Light</name><name sortKey="Light, Katrina J" sort="Light, Katrina J" uniqKey="Light K" first="Katrina J." last="Light">Katrina J. Light</name><name sortKey="Luty, Suzanne E" sort="Luty, Suzanne E" uniqKey="Luty S" first="Suzanne E." last="Luty">Suzanne E. Luty</name><name sortKey="Miller, Allison L" sort="Miller, Allison L" uniqKey="Miller A" first="Allison L." last="Miller">Allison L. Miller</name><name sortKey="Mulder, Roger T" sort="Mulder, Roger T" uniqKey="Mulder R" first="Roger T." last="Mulder">Roger T. Mulder</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/StressCovidV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002309 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002309 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= StressCovidV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:A4F78EDBF3F904AB205F89D64F4B27BA47774FE7
|texte= Preliminary evidence for an association between a dopamine D3 receptor gene variant and obsessive‐compulsive personality disorder in patients with major depression
}}
| This area was generated with Dilib version V0.6.33. |  |